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مقاله
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Abstract
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Title:
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Effects of Curcumin-Loaded Chitosan Nanoparticles on Corneal Permeation
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Author(s):
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Mehrnaz Moattari1, Farahnaz Moattari 2, Gholamreza Kaka*3, Homa Mohseni Kouchesfahani*1, Majid Naghdi4, Seyed Homayoon Sadraie3
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Presentation Type:
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Poster
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Subject:
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Glaucoma
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Others:
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Presenting Author:
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Name:
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Mehrnaz Moattari
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Affiliation :(optional)
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Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran
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E mail:
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mhr.moattari@gmail.com
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Phone:
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07136489485
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Mobile:
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09177192939
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Purpose:
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Curcumin (CUR) could be a striking free radical scavenging molecule in ocular disease. In this study, the effects of Curcumin-loaded chitosan (CS) nanoparticles on corneal permeation was assessed.
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Methods:
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CS NPs was prepared by the ionic gelation method using CS and tripolyphosphate (TPP). Ex-vivo corneal permeation of CUR from CUR NPs / CUR loaded NPs were determined using modified side by side Franz diffusion cell.
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Results:
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Ex-vivo corneal permeation of CUR was higher from CUR loaded formulation increased significantly in comparison with CUR alone containing NPs and free CUR dispersion (p<0.05).
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Conclusion:
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Taken together, use of Curcumin-loaded chitosan (CS) nanoparticles enhanced Ex-vivo corneal permeation.
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Attachment:
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1173Effects of Curcumin-Loaded Chitosan Nanoparticles on Intra Ocular Pressure.pptx
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