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مقاله
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Abstract
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Title:
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Therapeutic effect of intravitreal lanosterol on cataract in rabbit model
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Author(s):
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Gholamhossein Yaghoobi, Malihe Nikandish,fateme salmani
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Malihe Nikandish
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Affiliation :(optional)
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ophthalmology department,valiasr hospital,birjand, iran.
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E mail:
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nikandishm@bums.ac.ir
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Phone:
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05118438517
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Mobile:
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09153176152
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Purpose:
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To evaluate the safety and efficacy of intra vitreal lanosterol on cataract treatment in rabbit model
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Methods:
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Ten Adult male New Zealand white healthy rabbits received intravitreal single injection of 0.1 ml from 0.01% w/v of sodium selenite solution in both eyes for Cataract induction . One week after cataract creation twice intravitreal lanosterol (100µg) loaded nanoparticles was injected with two weeks interval in the left eye and the right eye was considered as a control . After maximum pupillary dilatation animals were assessed with slit lamp and direct ophthalmoscopy at weeks 2,4 and 6 for cataract change and side effect (PS formation) . Lens opacity evaluated using WHO cataract grading system. After data collection, analysis was done by Friedman test for cataract change and Fisher exact test for side effect evaluation.
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Results:
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Data analysis using Friedman test showed no significant changes in grade of cataract in both lanosterol and control group after six weeks,(p=0.49). Fisher exact test result for posterior synechia evaluation showed significant correlation between intravitreal lanosterol and PS formation.(p=0.05)
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Conclusion:
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intravitreal lanosterol failed to reverse lens opacity in rabbit model, besides that our experiment has demonstrated that safety of intravitreal lanosterol is questionable.
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Attachment:
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