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مقاله
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Abstract
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Title:
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Heritability of corneal curvature and Pentacam topometric indices: a population based study
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Author(s):
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Samira Heydarian, Hassan Hashemi, Frida Jabbari-Azad, Mojgan Pakbin, Fereshteh Shokrollahzadeh, Nooshin Dadbin, AbbasAli Yekta, Hadi Ostadimoghaddam, Akbar Derakhshan, Mehdi Khabazkhoob
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Fereshteh Shokrollahzadeh
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Affiliation :(optional)
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Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
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E mail:
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f.shokrollahzadeh@gmail.com
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Phone:
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Mobile:
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09128151471
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Purpose:
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to investigate familial aggregation of anterior and posterior corneal curvature, corneal astigmatism and some corneal topometric indices using Pentacam
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Methods:
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Of the 3851eligible individuals who resided in the selected areas, 2779 people had the conditions for analysis. However, analysis was limited to families whose Pentacam measures were available for at least 2 family members, resulting in 1383 individuals in 382 families. All selected subjects had a set of examinations including refraction, uncorrected and corrected visual acuity, slit lamp Biomicroscopy and Pentacam imaging. Heritability estimation was used to calculate familial aggregation.
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Results:
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The results of our study showed a fairly high corneal curvature heritability. The heritability of K2 and K1 in the anterior surface were 58.60% and 55.82%, respectively. The heritability of posterior corneal curvature was slightly higher than that of anterior corneal curvature. The heritability of K2 and K1 in the posterior surface were 63.42% and 59.67%, respectively. In investigating the quantitative topographic indices of the cornea, index of surface variance (ISV), Central Keratoconus Index (CKI) and index of vertical asymmetry (IVA) had the highest levels of heritability (81.2%, 74.99% and 66.46%, respectively) while Keratometric power deviation (KPD) and Index of height asymmetry (IHA) had the lowest heritability levels (7.48% and 18.31% respectively).
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Conclusion:
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the familial aggregation and relatively high heritability of corneal curvatures and some keratoconus related indices such as ISV and IVA confirm a high correlation between these phenotypes and genetic factors and warrant further investigation of the genetic mechanisms in keratoconus.
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Attachment:
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