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مقاله
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Abstract
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Title:
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Effects of Curcumin-Loaded Chitosan Nanoparticles on Intra Ocular Pressure
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Author(s):
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Mehrnaz Moattari1, Farahnaz Moattari 2, Gholamreza Kaka*3, Homa Mohseni Kouchesfahani*1, Majid Naghdi4, Seyed Homayoon Sadraie3
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Presentation Type:
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Oral
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Subject:
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Glaucoma
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Others:
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Presenting Author:
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Name:
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Mehrnaz Moattari
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Affiliation :(optional)
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Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran
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E mail:
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mhr.moattari@gmail.com
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Phone:
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07136489485
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Mobile:
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09177192939
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Purpose:
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Reactive oxygen species such as superoxide, hydrogen peroxide and hydroxyl radicals are inducers of oxidative stress. Curcumin, as a strong scavenger, has important role in preventing ocular disease such as glaucoma.
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Methods:
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After preparation of chitosan nanoparticles, curcumin was added into chitosan solution for the formulation of drug loaded NPs. IOP reducing efficiency of curcumin loaded nanoparticles was assessed by using a tonometer after administration of CUR loaded nanoparticles on the corneal surface of left eyes' of experimental animals.
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Results:
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Our results showed that use of CUR loaded nanoparticles decreased the intra ocular pressure (IOP) effects significantly in comparison with CUR and chitosan nanoparticles alone (p<0.05).
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Conclusion:
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Taken together, use of Curcumin-loaded chitosan (CS) nanoparticles enhanced reduction of IOP which can be beneficial in treatment of glucoma.
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Attachment:
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