image 2 image 4
Skip Navigation Links
 Home 
 Congress Structure 
 Important Dates 
 Venue 
 Registration 
 Pre Registered 
 Abstracts 
 Scientific Program 
 Photo and Film Festival 
 Exhibition 
 Contact Us 
 Personal page 
       XXVIII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و هشتمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: The effect of a cationic peptide on the treatment of experimental infectious keratitis
Author(s): Hossein Aghamollaei,Khosrow Jadidi, Hamidreza Safabakhsh, Mehrdad Moosazade Moghadam,
Presentation Type: Oral
Subject: Cornea and Anterior Segment
Others:
Presenting Author:
Name: Khosrow Jadidi
Affiliation :(optional) Chemical Injuries Research Center, Systems biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran,Iran
E mail: kh.jadidi@gmail.com
Phone:
Mobile: 09121053475
Purpose:

Bacterial keratitis is an ocular infection with the potential to cause significant visual impairment. Exploring of new antimicrobial agents for treatment of antibiotic resistance keratitis is essential. In this study we introduced a cationic peptide with antibacterial activity on Staphylococcus aureus keratitis

Methods:

Safety of the cationic peptide was confirmed using the Draize scoring system previously. Efficacy of this peptide was evaluated by experimental infectious keratitis in rabbit eye. After stromal injection of S.areus , peptide was topically applied in test group and compared with other groups including PBS, gentamicin and synergy (gentamicin +peptide) . After treatment the eye were clinically graded and cornea was harvested for pathology and colony counting.

Results:

Colony forming unit in the peptide treated group is significantly lower than gentamicin and PBS-treated groups. ( P< 0.05). Pathology reports indicated that structure of cornea was normal after administration of peptide as antibacterial agent.

Conclusion:

This cationic peptide have significant potential for development as a new antibacterial agent for treatment of bacterial keratitis

Attachment:





Skip Navigation Links
        صفحه اصلی
        ساختار کنگره
        تاریخ های مهم
        مکان برگزاری
        ثبت نام
        ثبت نام شدگان
        اطلاعات هتل - رزرو
        مقالات
        برنامه کنگره
        جشنواره فیلم و عکس
        نمایشگاه
        تماس با ما
        صفحه شخصی
        جستجوی سخنران
        آرشیو کنگره سالهای گذشته
        شب کنگره چشم پزشکی
 
ورود شرکت کنندگان
نام کاربری :
کلمه عبور :
  کلمه عبور خود را فراموش کرده ام.
Total Visits
Find us on Social Media
Congress Count Down
Today Label
Last Month Label
Total Visitors Label