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       XXVIII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و هشتمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Maggot excretions/secretions: a novel candidate for treatment of bacterial keratitis
Author(s): Hossein Aghamollaei,Khosrow Jadidi, Hamed Zare, Hamidreza Safabakhsh, Seyed Aliasghar Mosavi
Presentation Type: Oral
Subject: Cornea and Anterior Segment
Others:
Presenting Author:
Name: Hossein Aghamollaei
Affiliation :(optional) Chemical Injuries Research Center, Systems biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran,Iran
E mail: aghamolaei22@gmail.com
Phone:
Mobile: 09122793682
Purpose:

Due to development of methiciline resistance Staphylococcus aureus (MRSA), development of new antimicrobial agents for treatments of S.aureus keratitis is desirable. Excretions/secretions (ES) from larvae of maggots (Lucilia sericata) showed antibacterial activity against a range of bacteria. The aim of this study is evaluation of safety and efficacy of larval ES for treatment of S. aureus keratitis.

Methods:

For safety evaluation, Right eye of four New Zealand rabbits were topically treated with ES each 30 min for 3 hours (total of seven drops/eye). Ocular toxicity was evaluated using the Draize scoring system. Efficacy evaluation was performed by intrastromal injection of MRSA into rabbit cornea. The rabbits were divided into three treatment groups including Phosphate buffer saline, gentamicin and ES extract. After treatment, the eyes were examined clinically by slit lamp. Finally, the corneas were harvested for colony counts and pathological examinations.

Results:

Safety evaluation by Draize testing showed that total score was equal to zero. Efficacy evaluation showed that two treatment groups (ES and gentamicine) were significantly different from the control group (P ? 0.05). After treatment, ES and gentamicine significantly reduced CFU compared with the untreated eyes. The mean bacterial count (CFU) for gentamicine, ES and untreated groups were 4×104, 2.1×106 and 3×108 respectively (P ? 0.05).

Conclusion:

In conclusion, the extraction from larvae of maggots is a safe and effective in treating keratitis mediated by MRSA. Isolation of ES component with antibacterial activity is recommended.

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